Amyloid- 1-42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1
نویسندگان
چکیده
منابع مشابه
Amyloid-β1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1.
GLT-1, the major glutamate transporter in the adult brain, is abundantly expressed in astrocytic processes enveloping synapses. By limiting glutamate escape into the surrounding neuropil, GLT-1 preserves the spatial specificity of synaptic signaling. Here we show that the amyloid-β peptide Aβ1-42 markedly prolongs the extracellular lifetime of synaptically released glutamate by reducing GLT-1 s...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2013
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.5274-12.2013